Surgical Experience in Pre-Operative Measurement of Cochlear Duct Length in Cochlear Implant Surgery.

Unlabelled: Cochlear implant surgery is an auditory prosthesis that helps to restore the hearing in people who have severe to profound sensorineural hearing loss. In view of the variations in individual's cochlear size, appropriate selection of cochlear electrode is important to enable appropriate pitch detection in cochlear implant surgery. In traditional 24 mm electrodes were used in earlier the days.

The Myositis Clinical Trials Consortium: an international collaborative initiative to promote clinical trials in adult and juvenile myositis.

Idiopathic inflammatory myopathies (IIM), or myositis, are a heterogeneous group of systemic autoimmune disorders that are associated with significant morbidity and mortality. Conducting high-quality clinical trials in IIM is challenging due to the rare and variable presentations of disease. To address this challenge, the Myositis Clinical Trials Consortium (MCTC) was formed.

The role of a vaccine booster for a fractional order model of the dynamic of COVID-19: a case study in Thailand.

This article addresses the critical need for understanding the dynamics of COVID-19 transmission and the role of booster vaccinations in managing the pandemic. Despite widespread vaccination efforts, the emergence of new variants and the waning of immunity over time necessitate more effective strategies. A fractional-order mathematical model using Caputo-Fabrizio derivatives was developed to analyze the impact of booster doses, symptomatic and asymptomatic infections, and quarantine measures.

Lipidomic profiling of mouse brain and human neuron cultures reveals a role for in mTOR-dependent neuronal migration.

Mutations in lipid regulator genes are a frequent cause of autism spectrum disorder, including those regulating phosphatidylinositol (PI) and phosphoinositide 3-kinase signaling. encodes a key acyltransferase in PI synthesis and is mutated in an autism-related condition with neurodevelopmental delay and epilepsy. Using liquid chromatography-tandem mass spectrometry, we analyzed the PI-associated glycerolipidome in mice and humans during neurodevelopment and found dynamic regulation at times corresponding to neural apoptosis in the brains of knockout mice.

Reducing severe intraventricular haemorrhage rates in <26-week preterm infants with bedside assessment and care bundle implementation.

Aim: To assess staff adherence to a 'Preterm Brain Injury Prevention Bundle', and its effectiveness in reducing severe intraventricular haemorrhage (IVH) rates and risk factors in extremely preterm infants born at <26 weeks' gestation.

Methods: Adherence to the bundle was assessed using a novel bedside assessment tool, with immediate feedback to bedside staff post-assessment. Data on IVH rates and associated risk factors were stratified by IVH severity, and compared between pre- and post-bundle implementation.