Publications by authors named "I P Smirnov"
One of the key factors of the interaction 'osteoplastic material-organism' is the state of the implant surface. Taking into account the fact that the equilibrium in regeneration conditions is reached only after the reparative histogenesis process is completed, the implant surface is constantly modified. This work is devoted to the numerical description of the dynamic bilateral material-medium interaction under close to physiological conditions, as well as to the assessment of the comparability of the model with and experimental results.
View Article and Find Full Text PDFAlthough macrophages in the meningeal compartments of the central nervous system (CNS) have been comprehensively characterized under steady state, studying their contribution to physiological and pathological processes has been hindered by the lack of specific targeting tools in vivo. Recent findings have shown that the dural sinus and its adjacent lymphatic vessels act as a neuroimmune interface. However, the cellular and functional heterogeneity of extrasinusoidal dural macrophages outside this immune hub is not fully understood.
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- * Research using single-cell RNA sequencing shows that pediatric low-grade gliomas (LGGs) have more exhausted CD8 T cells compared to high-grade gliomas in both children and adults.
- * Preclinical studies reveal that in LGGs, exhausted CD8 T cells are mainly found in tumor tissue and play a role in promoting tumor growth, and ICI treatments can reduce tumor proliferation through specific cytokine suppression rather than direct T cell killing.
In the context of the antimicrobial therapy crisis, the significance of studying and implementing alternative treatment methods, particularly phage therapy, is increasingly evident. This study aimed to investigate the resistance of clinical Staphylococcus aureus ST239 strains to Herelleviridae phages through comparative genomics, transcriptomics, and proteomics. Analysis of resistant and sensitive S.
View Article and Find Full Text PDF[Studying the possibility of using methods for assessing expressive speech developmental disorders in children 3-6 years old].
Zh Nevrol Psikhiatr Im S S Korsakova
November 2024
Objective: To study the possibility of using methods (DP-3, speech therapy examination, neuropsychological study) to assess expressive speech development disorders in children aged 3 to 6 years inclusive.
Material And Methods: The study included 60 children with expressive speech disorder aged 3 to 6 years. At the initial stage, linguistic validation of the questionnaire was carried out according to generally accepted recommendations.