Publications by authors named "I P Poliakova"
Analysis of outpatients male patients aimed at Bone Density Measurement (Dual-Energy X-Ray Absorptiometry) during 2013. The study shows that men are sent to the examination for osteoporosis nearly 20 times less than women, while in men older than 60 years the decrease in bone mineral density was observed in more than 85% of cases. The identified violations of mineralization of bone tissue in men in different age periods and the main reason for referral for examination were analyzed.
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- Hypertrophic cardiomyopathy is a genetic heart disease that requires early diagnosis, but traditional methods are often ineffective due to the numerous causative genes and mutations involved.
- A custom AmpliSeq panel was developed to analyze key genes associated with cardiomyopathy using next-generation sequencing on both student cohorts and patients, applying statistical software for genetic marker selection.
- The findings revealed multiple gene substitutions linked to cardiomyopathy risk, along with protective genetic variants, demonstrating the potential of this method for improved risk prediction in patients.
In 2009-2010, 98 patients diagnosed with the coronary heart disease, but without the expressed metabolic violations, decompensated conditions and diseases were surveyed. Patients of 60-90 years were divided by age into two groups: younger than 75 years--47 people; 75 years and older--51; there were 41 women and 57 men; the ratio between women and men was 1:1.4; average age was 76.
View Article and Find Full Text PDFGenotype and allele frequencies of uncoupling proteins 2 and 3 genes (UCP2 and UCP3) and peroxisome proliferator-activated receptors genes (PPARA, PPARD and PPARG) were studied in 206 residents of the siege and in 139 individuals of more than 69 years old (control group). Studied polymorphisms included UCP2 (Ala55Val), UCP3 (C-55T), PPARA (G/C), PPARD (+294T/C), and PPARG (Pro12Ala). The G allele and the G/G genotype (PPARA) were overrepresented in the group of survivors and C/C (UCP3) genotype prevailed in the women of besieged Leningrad compared to relevant control groups of the persons of the same age who did not suffered hungry disaster.
View Article and Find Full Text PDFAim: To explore (1) intergroup differences in comfortable interpersonal distances (CIDs) and the use of coping strategies; (2) the association of these parameters with individual symptomatology; and (3) the interplay between CIDs and coping styles in patients with depression and schizophrenia.
Methods: The parameters of interest were assessed by means of standardized questionnaires: CID and Coping Inventory for Stressful Situations. Psychopathology was evaluated with the Beck Depression Inventory and Positive and Negative Syndromes Scale.