Effect of In Situ Acid Erosion on Structural and Optical Properties of Nanoparticulated Bisacrylic Resin With Different Surface Treatments.

Objective: To evaluate the influence of in situ acid erosion on the structural and optical properties of nanoparticulate bisacrylic resin with different surface treatments, evaluating surface roughness (Ra), knoop microhardness (KHN), color change (ΔE, ΔL, ΔC, ΔH), contrast (CR) and translucency (TP).

Methods: Eighty specimens were made (n = 10 per group) and the following surface treatments were applied: U-unpolished; A-polishing with Astropol rubber tips (Ivoclar); S-Biscover LV surface sealant (Bisco) and S-Palaseal surface sealant (kulzer). For the in situ experiment, 10 volunteers wore an intraoral appliance containing eight specimens (two specimens per experimental group), with only one specimen from each experimental group being subjected to the acid process.

High And Intermediate-High Risk Pulmonary Embolism Management: A 5-Year Intensive Care Unit Casuistic Review.

Background And Objectives: The optimal management of high-risk and intermediate-high-risk Pulmonary Embolism (PE) is a matter of ongoing debate. This paper aims to assess the short and long-term clinical outcomes associated with different treatment approaches for high-risk and intermediate-high-risk PE within an Intensive Care Unit (ICU) and identify potential areas for improvement.

Methods: We conducted a retrospective analysis of patients admitted to an ICU with high and intermediate-high-risk PE between January 2018 and December 2023.

Structured lipids from fish viscera and coconut oils improve weight gain and intestinal morphology of piglets at nursery phase.

Five metabolism assays were performed to determine the metabolizable energy (ME) content of soybean oil, coconut oil, fish viscera oil, physical mixture of coconut oil and fish viscera oil (3:2, in kg: kg) and structured lipid prepared from interesterification of fish viscera oil and coconut oil (3: 2, in kg: kg), and one assay to evaluate the effects of including these lipid sources in piglet diets on performance, digestibility of diets, incidence of diarrhea and intestinal morphometry at nursery phase. Soybean, coconut, fish viscera, physical mixture and structured lipid oils showed ME values of 8239, 8199, 8839, 8268 and 8523 kcal/kg DM respectively. In the performance trial, a total of 90 piglets with 23 days of age were distributed among 5 diets, differing in the lipid source used (soybean oil, coconut oil, fish viscera oil, physical mixture or structured lipid).

Anorexigenic and anti-inflammatory signaling pathways of semaglutide via the microbiota-gut--brain axis in obese mice.

Our study focused on a mouse model of obesity induced by a high-fat diet (HFD). We administered Semaglutide intraperitoneally (Ozempic ®-0.05 mg/Kg-translational dose) every seven days for six weeks.

The Antidepressant- and Anxiolytic-Like Effects of the Phosphodiesterase Type-5 Inhibitor Tadalafil are Associated with the Modulation of the Gut-Brain Axis During CNS Autoimmunity.

Multiple Sclerosis (MS) is a debilitating disease that severely affects the central nervous system (CNS). Apart from neurological symptoms, it is also characterized by neuropsychiatric comorbidities, such as anxiety and depression. Phosphodiesterase-5 inhibitors (PDE5Is) such as Sildenafil and Tadalafil have been shown to possess antidepressant-like effects, but the mechanisms underpinning such effects are not fully characterized.