A Homozygous Deletion of the DPY19l2 Gene is a Cause of Globozoospermia in Men from the Republic of Macedonia.

Globozoospermia is a rare but severe teratozoospermia, characterized by ejaculates consisting completely of round-headed spermatozoa that lack an acrosome or, in partial globozoospermia, containing a variable proportion (20.0-90.0%) of acrosomeless spermatozoa.

Genetic variation of the brca1 and brca2 genes in macedonian patients.

The most significant and well characterized genetic risk factors for breast and/or ovarian cancer are germline mutations in the BRCA1 and BRCA2 genes. The BRCA1 and BRCA2 gene mutations strikingly increase breast cancer risk, suggesting that polymorphisms in these genes are logical candidates in seeking to identify low penetrance susceptibility alleles. The aim of this study was to initiate a screen for BRCA1/2 gene mutations in order to identify the genetic variants in the Republic of Macedonia, and to evaluate the association of several single nucleotide polymorphisms (SNPs) in these genes with breast cancer risk.

[Correlations between changes in hearing and cerebral hemodynamics in patients with chronic alcoholism].

Seventy eight chronic alcoholics, aged 19 to 50 years, were exposed to audiologic and rheoencephalographic examinations. Tone hearing impairment was found in all subjects. The recruitment or greater than normal increment of loudness was primarily identified in patients of Group 1 that comprised those who consumed alcohol from 1 to 10 years.