Targeted Synthesis and Study of Anti-tyrosinase Activity of 2-Substituted Tetrahydrobenzo[4,5]Thieno[2,3-d]Pyrimidine-4(3H)-One.

Background: The high prevalence of skin hyperpigmentation makes it necessary to search for remedies that could hinder this process. Among such substances, tyrosinase inhibitors can be distinguished, which may be pyrimidine derivatives.

Objectives: This study aimed to investigate new compounds with anti-tyrosinase activity in 2-substituted tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one by an in vitro analysis and investigating their molecular docking.

[Comparative antioxidant and antihypoxic activities of new 1,4-dihydro-4-oxopyrimidine derivative--compound PDMpT.HCl and mexidol].

Compound PDMpT.HCI reduces intensity of lipoperoxidation, activates antioxidant system and increases animal life expectancy under hypoxic circumstance.