[Melfalan in the treatment of proliferative vitreoretinopathy (experimental study)].

Purpose: To study of the effectiveness of the drug Melphalan as an antiproliferative agent during experimental proliferative vitreoretinopathy (PVR).

Material And Methods: The experimental study used data from 24 eyes of 12 Chinchilla rabbits weighing 2.5-3.

Development of In Vivo Model of Intraocular Retinoblastoma.

Here we describe creation of a model of intraocular retinoblastoma on 4 mature immunodeficient BALB/c nude mice of both sexes. A suspension of the primary retinoblastoma culture was injected into each of the 8 eyes of the test animals. The injections were performed under the control of an operating microscope using insulin syringes with a diameter of 29G transsclerally into the subretinal space in a volume of 0.

Morphological Changes in the Retina Under Conditions of Experimental In Vivo Regional Ischemia/Reperfusion.

Two models of retinal ischemia/reperfusion were developed in an experiment on rats and structural changes in eye tissues in the early and late postischemic periods were studied. Ischemia/reperfusion was modeled by elevation of intraocular pressure to 110 mm Hg for 30 min with air injection into the anterior chamber of the eye with a special device or subconjunctival administration of 0.2 ml 4×10 M endothelin-1.

[The significance of fibroblasts in experimental modeling of proliferative vitreoretinopathy].

Aim: to investigate the role of heterogeneous fibroblasts in the development of epiretinal membrane in eyes with modeled proliferative vitreoretinopathy.

Material And Methods: The material for investigation were 6 eyes of 3 Chinchilla rabbits. Suspended fibroblasts (fibroblasts of the human skin - 200000 cells in 0.

[Experimental realization of minimally invasive techniques of scleral collagen cross-linking].

Aim: To realize two minimally invasive techniques of scleral collagen cross-linking (SXL) at the equator and posterior pole of the eye: 1) targeted irradiation of the region with ultraviolet A (UVA) and 2) sub-Tenon injection of Sklerateks.

Material And Methods: To perform UVA-SXL, a tool was developed that includes a UV-LED light source (370 nm, 3 mW/cm2) and a polymer-coated silica multimode optical fiber located in one of the two channels of a detachable metal tip. The other channel is used to deliver riboflavin to the scleral surface.