Publications by authors named "I P J Alwayn"
Background And Aims: Hepatic steatosis (HS), particularly macrovesicular steatosis (MaS), influences transplant outcomes. Accurate assessment of MaS is crucial for graft selection. While traditional assessment methods have limitations, non-invasive spectroscopic techniques like Raman and reflectance spectroscopy offer promise.
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- Abdominal Normothermic Regional Perfusion (aNRP) is a technique used before organ donation that helps evaluate organ quality during controlled donation after circulatory death (cDCD).
- A study compared pancreatic islet isolation outcomes from aNRP donors to those from cDCD and Donation after Brain Death (DBD) donors, finding that aNRP yielded significantly more islets.
- The study showed that islets from aNRP donors demonstrated good functionality, suggesting that this technique could enhance the availability and quality of pancreases for islet transplantation.
Introduction: A growing interest in renal normothermic machine perfusion (NMP) has resulted in more clinically available perfusion devices. While all perfusion systems have the same aim, there are significant differences in their circuits, pumps, sensors, and software. Therefore, our objective was to assess the impact of different perfusion protocols and devices on kidney function and perfusion parameters during NMP.
View Article and Find Full Text PDFIn this study, 10 years of procurement quality monitoring data were analyzed to identify potential risk factors associated with procurement-related injury and their association with long-term graft survival. All deceased kidney, liver, and pancreas donors from 2012 to 2022 and their corresponding recipients in the Netherlands were retrospectively included. The incidence of procurement-related injuries and potential risk factors were analyzed.
View Article and Find Full Text PDFBackground: In June 2021, the first robot-assisted donor nephrectomy (RADN) was performed at the Leiden University Medical Center (LUMC), the Netherlands. The goal of this study was to investigate whether this procedure has been implemented safely and efficiently.
Methods: RADN was retrospectively compared to laparoscopic donor nephrectomy (LDN) performed during the same time period (June 2021 until November 2022).