[The hooded allele and selection of wild Norway rats Rattus norvegicus for behavior].

Selection of wild gray rats for domestication (tame behavior) resulted in a sharp increase in the frequency of heterozygotes at the h allele of hooded, the main locus of rat depigmentation. The observed effect of the selection on the manifestation of the h allele is compared with similar effects giving rise to piebaldness in other animals subjected to experimental domestication. The results are discussed in terms of genetic specificity of piebaldness and of the selection vector.

[Effect of propranolol on the indicators of carbohydrate metabolism and lipid transport in patients with diabetes mellitus type 2].

The paper is concerned with some data on the time course of indices of carbohydrate metabolism and lipid spectrum in patients with type II diabetes mellitus with concomitant CHD or arterial hypertension during therapy with mean doses of propranolol. The course treatment with propranolol resulted in the deterioration of carbohydrate metabolic indices and unfavorable shifts in the lipid spectrum of some patients. Patients on insulin therapy might demonstrate a significant decrease in the blood sugar level after physical exercise.

[Changes in the indices of carbohydrate metabolism, of the lipoprotein spectrum and of the blood coagulation system in men with ischemic heart disease undergoing long-term propranolol treatment].

The paper is concerned with evidence of the time course of blood sugar, lipoprotein spectrum and some values of the blood coagulation system in patients with CHD on prolonged propranolol therapy in comparison with their natural time course in a similar group of patients with CHD receiving no therapy. Propranolol therapy for 2 yrs. produced no changes in the lipoprotein spectrum and blood fibrinogen.

[Changes in the resting ECG in males with impaired carbohydrate tolerance of different degrees without clinical symptoms of ischemic heart disease and arterial hypertension].

The resting ECGs were analyzed in males aged 20-60 years with various tolerance to carbohydrates. There were statistically significant differences between the values characterizing the functions of automatism and conductivity on the resting ECG in patients with diabetes mellitus without any clinical symptoms of coronary heart disease (CHD), arterial hypertension, cardiac failure and other chronic diseases and in healthy males with the normal tolerance to carbohydrates. in patients with borderline impairments of carbohydrate tolerance (CT), these parameters occupied an intermediate position between the corresponding values in patients with diabetes mellitus and in subjects with the normal tolerance to carbohydrates.

[Evaluation of the stability and prognostic significance of identification of various risk factors of ischemic heart disease in 50 to 59-year-old men].

The authors present the data on the prevalence of coronary heart disease (CHD) and its risk factors, on the incidence of new cases of CHD and the associated mortality in the unorganized population of 50-59-year-old men of Moscow as well as findings on the natural variability of risk factors obtained over six years in a follow-up study. The relationship between the CHD incidence on the one hand and the baseline arterial pressure levels, excessive body weight and smoking habit on the other is evaluated. Arterial hypertension is shown to be the most prognostic risk factor of CHD in the unifactorial analysis.