[Immunomodulating action of interferon in congenital and experimental thymus-dependent immunodeficiency].

A study of immunomodulating action of mouse alpha/beta interferon (IFN) was performed in conditions of congenital and experimental thymus-dependent immune deficiency. The action of IFN was assessed in vivo, with IFN injected intraperitoneally. It was shown that IFN did not change killer effect of lymphocytes in the reaction of stem cell inactivation in "nude" mice, but enhanced antibody and rosette formation in the spleen of these animals.

[Stem cell inactivation by allogenic lymphocytes: characteristics of suppressor cells blocking the killer action of syngeneic lymphocytes].

The role of different T lymphocyte subpopulations in the process of allogeneic haemopoietic stem cell inactivation has been studied. The T lymphocyte subpopulations were fractionated in vivo using the homing properties (to the spleen and lymph nodes) plus sensitivity for ALS in vivo (recirculation properties), for thymectomy, for anti-Thy 1 serum in vitro and some others. The results obtained indicate that not only the killer lymphocytes, that provide stem cell inactivation, but also the suppressor cells, that provide inhibition of inactivation, take part in the reaction for allogeneic stem cells.

[A study of two non-complementary H-2 mutations in mice using skin transplantation and serologic analysis].

Hz1 and M505 are two mutants affected the Kend of H-2 major histocompatibility system in mouse. Inability of M505 to complement Hz1 is considered as an evidence that the same gene is altered by both mutations. The gained antigens of two mutants can cross-react in vivo, and the lost antigenic determinants are not identical as revealed in skin grafting tests with presensitized recipients.