Publications by authors named "I P Borysenko"
Article Synopsis
- The study focuses on the design and synthesis of a new group of compounds called 2-benzylidenebenzofuran-3-ones (aurones), which are effective inhibitors of the enzyme CK2.
- A range of these aurones demonstrated strong inhibitory effects on CK2, with several compounds showing nanomolar activity in tests, indicating high potency.
- The most effective compound identified, labeled 12m (BFO13), achieved significant performance metrics, showcasing an enhanced lipophilic efficiency and an IC value of 3.6 nM, making it comparable to top CK2 inhibitors.
The general proteolytic activity and the level of proteinase inhibitors in salivary glands and blood serum of rats with acute stress were studied during the experiment. It was established that a trustworthy decrease of general proteolytic activity salivary gland homogenate was induced by activation of thermoacidstable inhibition in them.
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