[Antidiabetogenic action of Pro-Gly-Arg and Pro-Gly-Pro-Arg peptides after their intranasal chronic administration to animals].

It was shown that chronic (over 7 days) intranasal injection of the Pro-Gly-Arg tripeptide to rats in the dose 1 mg/kg before the injection of a diabetogenic dose of alloxan, promotes effective defense against development of insulin dependent diabetes mellitus. At the same time, the tetra-peptide Pro-Gly-Pro-Arg did not show a hypoglycemic affect during diabetes mellitus provocation. Administration of Pro-Gly-Arg and Pro-Gly-Pro-Arg peptides also activates anticoagulation potential.

[Research of interactions in the dopamine-serotonin-somatostatin system promises new outlook in fundamental and practical respects].

Dopamine and serotonin are the two important key neurotransmitters, which participate in the formation and regulation of various physiological parameters in the normal and pathological states. It is very interesting and important in both fundamental and practical respect to analyze interactions of dopamine and serotonin with somatostatin--a peptide hormone suppressing the secretion of many other regulatory peptides and various bioactive substances. In the present work, a huge amount of experimental data on the interactions of dopamine and serotonin with somatostatin was collected and analyzed.

[A comparative analysis of distribution of glyprolines administered by various routes].

The distribution of the glyprolines Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selanc) was analyzed and compared in tissues of rat organs after different ways of their administration using the peptides uniformly labeled with tritium. Comparative data on changes in concentrations of the peptides in the rat organs after their intraperitoneal, intranasal, intragastric, and intravenous administration are given. The intranasal administration of both peptides was shown to be optimal for the delivery of glyproline molecules in the CNS.

[The interaction of serotonin and dopamine systems with the systems of the regulatory peptides oxytocin, vasopressin, and prolactin under normal conditions and during pregnancy].

The authors studied a vast volume of unsystematized literature data (between 1970 and 2006) on the interaction of the neurotransmitters serotonin and dopamine with the hormonal peptide regulators prolactin, oxytocin, and vasopressin. Analysis of the results of studies made it possible to create a data base and analyze complex induction interactions between serotonin and dopamine and the three regulatory peptides under various physiological conditions: non-pregnancy, early and late stages of pregnancy, lactation, and maternal behavior. The roles of serotonin and dopamine in the formation of reproductive and maternal behavior were determined.