PATTERN OF MORBIDITY OF PATIENTS ADMITTED TO NIGERIAN TERTIARY-LEVEL HOSPITALS: INSIGHTS FROM THE MOHOPA STUDY.

Background: There is a paucity of nationally representative data on the pattern of morbidity of hospitalised medical patients in Nigeria. We hereby provide insights from the MOHOPA (Pattern of Morbidities, Mortality and Healthcare Financing of Hospitalised Medical Patients in Hospitals) study on the pattern of morbidity among patients admitted to the medical wards of Nigerian tertiary-level hospitals.

Methods: At least 100 patients admitted to the medical and emergency wards of 7 tertiary-level hospitals, spread across the 6 geopolitical zones of Nigeria and the Capital City of Abuja, were consecutively recruited to join the study after obtaining written informed consent.

Beyond Amyloid: A Machine Learning-Driven Approach Reveals Properties of Potent GSK-3β Inhibitors Targeting Neurofibrillary Tangles.

Current treatments for Alzheimer's disease (AD) focus on slowing memory and cognitive decline, but none offer curative outcomes. This study aims to explore and curate the common properties of active, drug-like molecules that modulate glycogen synthase kinase 3β (GSK-3β), a well-documented kinase with increased activity in tau hyperphosphorylation and neurofibrillary tangles-hallmarks of AD pathology. Leveraging quantitative structure-activity relationship (QSAR) data from the PubChem and ChEMBL databases, we employed seven machine learning models: logistic regression (LogR), k-nearest neighbors (KNN), random forest (RF), support vector machine (SVM), extreme gradient boosting (XGB), neural networks (NNs), and ensemble majority voting.

Chronic HIV infection and health related quality of life in resource poor settings-an assessment from South East Nigeria.

Background: Health-related quality of life reflects a patient's general subjective perception of the effect of an illness or intervention on physical, psychological and social aspects of daily life. HIV infection is a major public health problem especially in developing countries where poor health infrastructure and poverty are prevalent. This paper addresses the quality of life in patients with chronic HIV infection in South East Nigeria and addresses issues that may help improve the current situation.

Conceptual framework for establishing the African Stroke Organization.

Africa is the world's most genetically diverse, second largest, and second most populous continent, with over one billion people distributed across 54 countries. With a 23% lifetime risk of stroke, Africa has some of the highest rates of stroke worldwide and many occur in the prime of life with huge economic losses and grave implications for the individual, family, and the society in terms of mental capital, productivity, and socioeconomic progress. Tackling the escalating burden of stroke in Africa requires prioritized, multipronged, and inter-sectoral strategies tailored to the unique African epidemiological, cultural, socioeconomic, and lifestyle landscape.