Publications by authors named "I Onorati"
Background: A 51-year-old woman was referred to our department due to chronic dry cough lasting six years without an etiological diagnosis. The patient suffered from chronic deterioration in her quality of life due to a persistent cough that sounded like a barking seal.
Case Presentation: A severe form of malacia involving the inferior third of trachea and the main bronchi was diagnosed.
Synthetic tubular grafts currently used in clinical context fail frequently, and the expectations that biomimetic materials could tackle these limitations are high. However, developing tubular materials presenting structural, compositional and functional properties close to those of native tissues remains an unmet challenge. Here we describe a combination of ice templating and topotactic fibrillogenesis of type I collagen, the main component of tissues' extracellular matrix, yielding highly concentrated yet porous tubular collagen materials with controlled hierarchical architecture at multiple length scales, the hallmark of native tissues' organization.
View Article and Find Full Text PDFLung cancer represents the most lethal cancer worldwide. Surgery is the treatment of choice for early-stage non-small cell lung cancer, with an overall survival that can reach 90% at 5 years, but its detection is difficult to achieve due to the lack of symptoms. Screening programs are crucial to identify small cancer.
View Article and Find Full Text PDFArticle Synopsis
- Recent studies show that using stented cryopreserved aortic allografts for tracheobronchial replacement is effective, especially for patients with severe tracheal cancer.
- The study analyzed 13 patients with extensive tracheal cancer from a larger registry, focusing on their surgical outcomes and complications.
- Findings indicate that the procedure had no 30-day mortality, a high rate of complete resection, and 84.6% of patients were alive at the last follow-up, although some experienced late complications.