Publications by authors named "I Omori"
Article Synopsis
- Several studies have established a connection between subway and ambient particle exposure and negative health effects, like inflammation and vascular issues, but the combined impact of these pollutants with lipopolysaccharide (LPS) remains largely unexplored.
- The research focused on the health effects of iron oxide particles (found in subway dust) compared to urban aerosols and vehicle exhaust, finding that iron oxides are more harmful, causing greater endothelial cell damage and altering key vascular proteins.
- When iron oxides are combined with LPS, there's a notable increase in inflammation and immune responses in the body, indicating that subway particles may pose greater health risks than other types of urban pollutants.
Article Synopsis
- Previous studies have noted the mutational landscape of extramammary Paget's disease (EMPD), but the impact of genetic alterations on prognosis, especially CDKN2A loss, was not previously explored.* -
- In a retrospective study involving 167 registered EMPD cases, researchers found that CDKN2A loss was the most common variant, and both CDKN2A and BRCA2 mutations were linked to worse patient outcomes.* -
- Patients with CDKN2A mutations had a significantly poorer prognosis compared to those without, and those with BRCA2 mutations also fared worse, indicating the importance of genetic profiling in understanding EMPD prognosis.*
Systemic sclerosis (SSc) is a connective tissue disease characterized by aberrant immune activation, vascular injury, and fibrosis of the skin and internal organs. Ly6/PLAUR domain-containing protein 1 (LYPD1) was reported to be secreted and to have various physiological functions such as anti-angiogenic effects. Here we investigated serum LYPD1 levels in SSc patients and the association of serum LYPD1 levels with clinical features of SSc.
View Article and Find Full Text PDFA 66-year-old man presenting with cStage Ⅲc rectal cancer underwent laparoscopic low anterior resection(D3 lymph node dissection and R0 resection)following neoadjuvant chemoradiotherapy(capecitabine, 45 Gy/25 Fr)and received adjuvant chemotherapy(CAPOX). A year after surgery, abdominal contrast-enhanced computed tomography revealed recurrence near the rectal anastomosis with prostate invasion. The patient underwent robot-assisted abdominoperineal resection alongside en bloc prostatectomy and vesico-urethral anastomosis after 12 courses of neoadjuvant chemotherapy(FOLFIRI and panitumumab).
View Article and Find Full Text PDFPsoriasis is a persistent inflammatory skin disease thought to arise as a result of the infiltration of inflammatory cells and activation of keratinocytes. Recent advances in basic research and clinical experience revealed that the interleukin (IL)-23/IL-17 axis has been identified as a major immune pathway in psoriasis. However, it remains unclear how keratinocyte factors contribute to the pathology of psoriasis.
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