Integrated water resource management in the Segura Hydrographic Basin: An artificial intelligence approach.

Managing resources effectively in uncertain demand, variable availability, and complex governance policies is a significant challenge. This paper presents a paradigmatic framework for addressing these issues in water management scenarios by integrating advanced physical modelling, remote sensing techniques, and Artificial Intelligence algorithms. The proposed approach accurately predicts water availability, estimates demand, and optimizes resource allocation on both short- and long-term basis, combining a comprehensive hydrological model, agronomic crop models for precise demand estimation, and Mixed-Integer Linear Programming for efficient resource distribution.

Diastereoselective ZnCl-Mediated Joullié-Ugi Three-Component Reaction for the Preparation of Phosphorylated -Acylaziridines from 2-Azirines.

We disclose a direct approach to the diastereoselective synthesis of phosphorus substituted -acylaziridines based on a one-pot ZnCl-catalyzed Joullié-Ugi three-component reaction of phosphorylated 2-azirines, carboxylic acids and isocyanides. Hence, this robust protocol offers rapid access to an array of -acylaziridines in moderate-to-good yields and up to 98:2 dr for substrates over a wide scope. The relevance of this synthetic methodology was achieved via a gram-scale reaction and the further derivatization of the nitrogen-containing three-membered heterocycle.

Visual Analytics Platform for Centralized Covid-19 Digital Contact Tracing.

The Covid-19 pandemic and its dramatic worldwide impact have required global multidisciplinary actions to mitigate its effects. Mobile phone activity-based digital contact tracing (DCT) via Bluetooth Low Energy (BLE) technology has been considered a powerful pandemic monitoring tool, yet it sparked a controversial debate about privacy risks for people. In order to explore the potential benefits of a DCT system in the context of Occupational Risk Prevention, this paper presents the potential of Visual Analytics methods to summarize and extract relevant information from complex DCT data collected during a long-term experiment at our research centre.

Heterogeneity of Cholangiocarcinoma Immune Biology.

Cholangiocarcinomas (CCAs) are aggressive tumors arising along the biliary tract epithelium, whose incidence and mortality are increasing. CCAs are highly desmoplastic cancers characterized by a dense tumor microenvironment (TME), in which each single component plays a fundamental role in shaping CCA initiation, progression and resistance to therapies. The crosstalk between cancer cells and TME can affect the recruitment, infiltration and differentiation of immune cells.

The Impact of Levetiracetam and Valproate on Platelet Functions-A Double-Blind, Placebo-Controlled Crossover Study.

It is known that valproate inhibits platelet functions; however, the exact mechanisms are not clearly identified. We studied 12 healthy adult volunteers (1 female, 11 male; age range 31.7 ± 7.