Publications by authors named "I O Kuznetsov"
The course of COVID-19 is highly variable, with genetics playing a significant role. Through large-scale genetic association studies, a link between single nucleotide polymorphisms and disease susceptibility and severity was established. However, individual single nucleotide polymorphisms identified thus far have shown modest effects, indicating a polygenic nature of this trait, and individually have limited predictive performance.
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- The study aims to evaluate if machine learning can effectively predict early outcomes of laparoscopic nephron-sparing surgery (NSS) for kidney tumors, taking the surgeons' experience into account.
- Analyzing data from 320 surgery cases by four surgeons, the research utilizes eXtreme Gradient Boosting and the SHAP method to identify key factors influencing surgical success, including patient demographics, tumor characteristics, and the surgical learning curve.
- Results show that the SHAP method offers valuable insights from the machine learning model, highlighting the importance of certain new features in predicting surgical outcomes such as procedure duration and postoperative kidney function.
Objective: To systematically evaluate the impact of the Trendelenburg position on hemodynamic parameters in adult patients.
Design: Systematic literature review and meta-analysis using PubMed and Medline.
Setting: All prospective interventional studies comparing the hemodynamic characteristics of patients in the horizontal supine position and Trendelenburg position.
Article Synopsis
- Machine learning (ML) is increasingly important for predicting sepsis, a critical condition where timely intervention is crucial; this study explores the effectiveness of ML models in clinical settings.
- Researchers analyzed 73 studies involving nearly 458,000 patients and found that ML models, particularly Neural Networks and Decision Trees, performed better than traditional scoring systems, achieving a pooled AUC of 0.825.
- The study emphasizes the need for standardized practices in reporting and validating ML models to enhance their clinical application and effectiveness in predicting sepsis across diverse patient populations.
High-affinity and specific agents are widely applied in various areas, including diagnostics, scientific research, and disease therapy (as drugs and drug delivery systems). It takes significant time to develop them. For this reason, development of high-affinity agents extensively utilizes computer methods at various stages for the analysis and modeling of these molecules.
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