[Correlation of the clinical pharmacological action of a single dose of fenazepam with the EEG dynamics and pharmacokinetics].

Interaction between the clinical, EEG-effects and phenazepam concentration in the blood was studied in 111 patients with neurotic disorders after intake of the test drug dose (2 mg) administered singly and on the 14th day of the treatment. It was established that EEG changes commonly induced by benzodiazepines supervene primarily within the interval of 1 to 3 h after a single intake which correlates with the maximal degree of the tranquilizing, somnolent and myorelaxant drug action. It was demonstrated that the clinical and EEG-effects occur before attainment of the maximal phenazepam concentration and then become less potent, with preservation of the high blood drug level.

[Relation between the effect of tranquilizers and various features of personality structure among patients with borderline states].

The authors revealed differences in the clinico-psychopathological structure, therapeutic time-course and efficiency of the treatment by tranquilizers (e. g. phenazepam, a drug whose effect is typical for the entire group of tranquilizers) in 86 patients with borderline states, the nature of differences depending on the typological characteristics of their personality structure.