Publications by authors named "I O Baas"
Background: Oncoplastic breast conserving surgery (OP-BCS) is becoming increasingly popular to avoid mastectomy or optimize cosmetic outcomes of breast conserving surgery (BCS). Few studies have compared clinical outcomes and patient-reported outcomes (PROs) of OP-BCS to conventional BCS (C-BCS). This study aims to compare clinical outcomes and short and long-term PROs after OP-BCS and C-BCS in a large prospective breast cancer cohort.
View Article and Find Full Text PDFBackground: Low-grade serous and endometrioid ovarian cancers and adult-type granulosa cell tumors are rare ovarian malignancies that show high estrogen receptor positivity. Recurrences of these subtypes of ovarian cancer are often treated with conventional chemotherapy, although response rates are disappointing.
Primary Objective: To determine the overall response rate of the combination therapy of abemaciclib and letrozole in patients with estrogen receptor-positive rare ovarian cancers.
Immunotherapy for Gestational Trophoblastic Neoplasia: A New Paradigm.
Gynecol Obstet Invest
June 2024
Article Synopsis
- Immune checkpoint inhibitors (CPI), specifically targeting PD-1/PD-L1, show effectiveness in treating gestational trophoblastic neoplasia (GTN), especially in high-risk and chemotherapy-resistant cases.
- A review of existing data indicated that out of 133 patients treated with various CPI agents, 85 achieved complete remission, with 77 from high-risk groups.
- Future research will focus on the optimal timing for CPI use, potential combinations with chemotherapy, and impacts on fertility, while addressing concerns over the high cost of treatment.
Background: Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare aggressive ovarian malignancy mainly affecting children, adolescents, and young adults. Since the discovery of mutations in the SMARCA4 gene in 2014, SCCOHT has become the subject of extensive investigation. However, international uniform treatment guidelines for SCCOHT are lacking and the outcome remains poor.
View Article and Find Full Text PDFArticle Synopsis
- During the second wave of SARS-CoV-2, a study assessed the quality of life (QoL), physical functioning, and psychosocial well-being in breast cancer patients, following an observed decline during the first wave.
- Results indicated that patient-reported QoL and well-being remained stable or improved, with a notable decrease in emotional loneliness.
- The analysis involved comparing data from breast cancer patients across both waves and a similar non-cancer population, highlighting the resilience of patients during the pandemic.