Radiation-induced gene expression in MCF-7 cells.

Purpose: Detection of gene targets applicable to biological dosimetry and early detection of radiation-induced cell damage.

Materials And Methods: MCF-7 human mammary carcinoma cells were exposed to 2 and 6 Gy X-rays. Expression of 1176 genes was traced with the Atlas Human 1.

Proliferation kinetics and PCNA expression of HL-60 cells following ionizing irradiation and granulocytic differentiation.

The human promyelocytic leukaemia cell line, HL-60, was investigated with regard to proliferation and terminal differentiation following irradiation. The cells were X-irradiated and induced with 1.25% dimethyl sulfoxide (DMSO) towards the granulocytic lineage.