Behavioral Dysfunctions Caused by Pyridoxamine Deficiency in Drosophila melanogaster.

Pyridoxamine (PM) is one of the natural vitamins B6 (VB6) and functions as an endogenous inhibitor for the formation of AGEs (advanced glycation end products). The AGEs are implicated in aging, diabetes, and various neuropsychiatric disease, including schizophrenia, Alzheimer's disease, and Parkinson's disease. However, it is unclear whether the absence of PM per se accumulates AGEs in vivo and causes behavioral dysfunctions.

The surprising effects of sulfur: achieving long excited-state lifetimes in heteroleptic copper(i) emitters.

A series of heteroleptic [Cu(N^N)(P^P)][PF] complexes is reported in which N^N is a di(methylsulfanyl)-1,10-phenanthroline (2,9-, 3,8- or 4,7-(MeS)phen) or di(methoxy)-1,10-phenanthroline (2,9-, 3,8- or 4,7-(MeO)phen) and P^P is bis(2-(diphenylphosphano)phenyl)ether (POP) or 4,5-bis(diphenylphosphano)-9,9-dimethylxanthene (xantphos). The effects of the different substituents are investigated through structural, electrochemical and photophysical studies and by using DFT and TD-DFT calculations. Introducing methylsulfanyl groups in the 2,9-, 3,8- or 4,7-positions of the phen domain alters the composition of the frontier molecular orbitals of the [Cu(N^N)(P^P)] complexes significantly, so that ligand-centred (LC) transitions become photophysically relevant with respect to metal-to-ligand charge transfer (MLCT).

[Cu(POP)(N^S)][PF] and [Cu(xantphos)(N^S)][PF] compounds with 2-(thiophen-2-yl)pyridines.

A series of [Cu(POP)(N^S)][PF] and [Cu(xantphos)(N^S)][PF] compounds (POP = bis(2-(diphenylphosphino)phenyl)ether, xantphos = 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene) in which the N^S ligand is a 2-(thiophen-2-yl)pyridine (1), 2-(thiophen-2-yl)-6-methylpyridine (2), 2-(5-methylthiophen-2-yl)pyridine (3) or 2-(5-methylthiophen-2-yl)-6-methylpyridine (4) have been prepared and characterized in solution and the solid state. Single crystal structures of [Cu(POP)(1)][PF], [Cu(xantphos)(1)][PF], [Cu(xantphos)(2)][PF], [Cu(POP)(3)][PF]·CHCl, and [Cu(xantphos)(4)][PF] confirm chelating N^S and P^P ligands, and distorted tetrahedral copper(i) centres. There is close cation⋯anion association, particularly in [Cu(xantphos)(1)][PF].