Publications by authors named "I Nln"
Background: Viral infection outcomes vary widely between individuals, ranging from mild symptoms to severe organ failure and death, and it is clear that host genetic factors play a role in this variability. Type I interferon (IFN) is a critical anti-viral cytokine, and we have previously noted differences in type I IFN levels between world populations.
Methods: In this study, we investigate the interrelationship between regional European genetic ancestry, type I IFN levels and severe viral infection outcomes.
Article Synopsis
- Type I interferon (IFN) is essential for fighting viral infections, and certain genetic alleles associated with increased IFN activation are risk factors for systemic lupus erythematosus (SLE).
- A study involving nearly 1,200 patients with acute COVID-19 found that specific genetic variations in the IRF5, PRKG1, IRF7, and IRF8 genes influenced mortality rates, with certain variants showing stronger effects based on age and ancestry.
- Combining genetic data with blood biomarkers improved predictions of COVID-19 mortality, highlighting the importance of the IFN pathway in antiviral defense and suggesting that some SLE risk genes may offer protective effects against severe outcomes in viral infections.
Unlabelled: Type I interferon (IFN) is critical in our defense against viral infections. Increased type I IFN pathway activation is a genetic risk factor for systemic lupus erythematosus (SLE), and a number of common risk alleles contribute to the high IFN trait. We hypothesized that these common gain-of-function IFN pathway alleles may be associated with protection from mortality in acute COVID-19.
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