Publications by authors named "I Nixon"
The increasing popularity of the dihydrouracil motif in cereblon (CRBN) recruiting proteolysis-targeting chimeras (PROTACs) has necessitated the development of a facile, cost-effective, and high-yielding method for its introduction into molecules. To that end, we disclose herein an N-1 selective Pd-catalyzed cross-coupling of dihydrouracil with aryl electrophiles to provide access to medicinally relevant scaffolds in a single step. This approach exhibits excellent functional group tolerance and broad applicability to an abundance of (hetero)aryl halides and phenol derivatives and utilizes readily available catalyst/ligand systems.
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- - The study aimed to evaluate the safety and effectiveness of treatments for recurrent respiratory papillomatosis (RRP) in UK NHS hospitals, involving data collection from patients between April 2018 and August 2022, along with some retrospective data from earlier years.
- - A total of 304 patients (including 65 children) were analyzed; findings showed that children had a more severe form of RRP compared to adults, with microdebrider surgeries being the most common treatment.
- - The research concluded that RRP is more aggressive in children, treatment varies by age, and overall management was safe, with few complications and effective results; it highlighted the need for standardized reporting to better track disease progression and safety. *
Implication of surgical loupes on complications following thyroidectomy: a meta-analysis.
Eur Arch Otorhinolaryngol
October 2024
Article Synopsis
- - The study aimed to evaluate how effective surgical loupes are in preventing complications like recurrent laryngeal nerve (RLN) palsy and hypocalcemia after thyroid surgery.
- - A total of 813 patients from six studies were analyzed, showing that using loupes significantly reduced the incidence of temporary RLN palsy by about 41.8%.
- - Although trends suggested lower rates of permanent RLN palsy and hypocalcemia with loupes, these results were not statistically significant, indicating potential benefits that need further research.
Soft tissue sarcomas (STS), comprising approximately 1% of adult solid malignancies, are primarily treated with surgery, with the choice of perioperative treatment being a challenging and highly individualized decision. Clinical trials assessing neoadjuvant modalities in STS predominantly use clinical outcomes or radiologic response as endpoints, with pathologic complete response (pCR) not being employed as a designated study endpoint. Our systematic review aimed to assess the rates of pCR in clinical trials of different neoadjuvant modalities for STS and its correlation with patient clinical outcomes.
View Article and Find Full Text PDFSoft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues and can occur almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location, means that developing evidence-based guidelines is complicated by the limitations of the data available. This makes it more important that STS are managed by expert multidisciplinary teams, to ensure consistent and optimal treatment, recruitment to clinical trials, and the ongoing accumulation of further data and knowledge.
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