Publications by authors named "I Nicolas"

Objective: Previous studies have highlighted the relevance of perfectionism, self-esteem, and anxio-depressive symptoms in anorexia nervosa (AN). However, the relationships between these factors and cardinal eating disorders (ED) symptoms remain unclear, particularly in AN subtypes. This study aimed to examine their interconnections using network analysis.

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Objectives: Assessing the therapeutic potential of a novel antimicrobial pseudopeptide, Pep16, both and for the treatment of septic arthritis caused by .

Methods: Seven clinical isolates of (two MRSA and five MSSA) were studied. MICs of Pep16 and comparators (vancomycin, teicoplanin, daptomycin and levofloxacin) were determined through the broth microdilution method.

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Article Synopsis
  • * The new antimicrobial pseudopeptide Pep16 may enhance colistin's effectiveness and reduce resistance when combined, as shown in lab tests and mouse models.
  • * In tests, Pep16 alone was ineffective, but when combined with colistin, it significantly lowered bacterial counts and prevented colistin resistance in a murine peritonitis model.
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Anorexia nervosa is a psychiatric disorder that mainly affects women (sex ratio 1/10) and for which the prognosis remains poor (10% of deaths and high risk of chronicity). This disorder is associated with a risk of infertility explained by different physiopathological pathways. Thus, the clinical and subclinical forms of this disease may be over-represented in populations of women using medically assisted reproduction technologies.

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