Publications by authors named "I Nichiporuk"
Article Synopsis
- - Negative pressure breathing (NPBin) is a technique that lowers pressure in the respiratory tract during inhalation, aiming to boost blood flow to the heart and counteract fluid shifts in space.
- - This study analyzed the effects of NPBin for 25 minutes at pressure reductions of -10 to -25 cmHO, using various non-invasive measurement techniques to assess changes in circulation and respiration in healthy volunteers.
- - Results showed that NPBin increased tidal volume and decreased respiratory rate without significantly affecting overall minute ventilation, while circulatory parameters showed increased amplitude during breathing cycles, indicating a complex interaction between respiration and circulation.
Space flight factors are known to cause a malfunction in the human immune system and lead to damage to blood vessels. The hemostatic function of endothelium during space missions and its interaction with human immunity has not been determined so far. In this work, we investigated the markers of endothelial activation and damage (plasma concentrations of soluble thrombomodulin fraction (sTM), von Willebrand factor (vWF), highly sensitive C-reactive protein (hs-CRP)), as well as the level of D-dimer and compared them to the immunological parameters characterizing the state of human humoral and cellular immunity.
View Article and Find Full Text PDFIntroduction: Long-term confinement is known to be a stressful experience with multiple psycho-physiological effects. In the MARS500 project, a real-time simulation of a space-flight to Mars conducted in a hermetically isolated habitat, effects of long-term confinement could be investigated in a unique manner. The aim of this study was to evaluate effects of long-term-confinement on brain cytoarchitecture.
View Article and Find Full Text PDFSpace flight exerts a specific conglomerate of stressors on humans that can modulate the immune system. The mechanism remains to be elucidated and the consequences for cosmonauts in the long term are unclear. Most of the current research stems from short-term spaceflights as well as pre- and post-flight analyses due to operational limitations.
View Article and Find Full Text PDFBody composition and metabolic changes during a 520-day mission simulation to Mars.
J Endocrinol Invest
November 2018
Purpose: The "Mars-500 project" allowed to evaluate the changes in psychological/physiological adaptation over a prolonged confinement, in order to gather information for future missions. Here, we evaluated the impact of confinement and isolation on body composition, glucose metabolism/insulin resistance and adipokine levels.
Methods: The "Mars-500 project" consisted of 520 consecutive days of confinement from June 3, 2010 to Nov 4, 2011.