Publications by authors named "I Navarro Serrano"

The Eurasian griffon vulture (), a widely distributed scavenger, plays a crucial role in ecosystem health by consuming decomposing carcasses. Scavengers have adapted to avoid disease from the rotting carrion they feed on, probably through a specialized gut microbiome. This study aimed to characterize the gut microbiome of (n = 8) present in two rehabilitation centers in mainland Portugal and evaluate their potential as reservoirs of pathogens.

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Article Synopsis
  • Otitis externa (OE) in dogs is a common issue linked with various factors, with Pseudomonas aeruginosa being a key concern due to its resistance to multiple drugs and ability to form persistent biofilms.
  • The study aimed to compare the effectiveness of a new otological gel containing a synthetic peptide and lavender oil to traditional antibiotic gentamicin in eradicating P. aeruginosa biofilms.
  • Results showed that while gentamicin completely eliminated the bacteria after 24 hours, lavender oil was effective at 30 minutes, and both the otological gel and lavender oil demonstrated comparable performance against biofilms over time, suggesting alternative treatments for canine OE.
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The dissemination of multidrug-resistant (MDR) bacterial isolates in low- and middle-income countries, including several African countries, is a major concern. The poor sanitary conditions of rural and urban families observed in certain regions may favor the transmission of bacterial infections between animals and humans, including those promoted by strains resistant to practically all available antibiotics. In Angola, in particular, the presence of these strains in human hospitals has already been described.

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Transporters of the solute carrier superfamily (SLCs) are responsible for the transmembrane traffic of the majority of chemical substances in cells and tissues and are therefore of fundamental biological importance. As is often the case with membrane proteins that can be heavily glycosylated, a lack of reliable high-affinity binders hinders their functional analysis. Purifying and reconstituting transmembrane proteins in their lipidic environments remains challenging and standard approaches to generate binders for multi-transmembrane proteins, such as SLCs, channels or G protein-coupled receptors (GPCRs) are lacking.

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