Publications by authors named "I Narvaiza"
Article Synopsis
- Human brain behavior differences are linked to brain size and organization, which develop slowly in humans compared to other primates, a phenomenon known as neoteny.
- Research tracking neuronal development across various primate species revealed both similarities and unique distinctions in gene regulation, particularly focusing on the transcription factor GATA3.
- Downregulating GATA3 in human neurons sped up the development of action potentials, suggesting that gene regulation differences contribute to the slower maturation process seen in humans.
Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often does not recapitulate important species-specific developmental hallmarks. We utilize induced pluripotent stem cell (iPSC) technology to investigate the development of cortical pyramidal neurons following migration and maturation of cells grafted in the developing mouse cortex.
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- * The review highlights the role of mobile genetic elements, particularly non-LTR retrotransposons, which have influenced our genome over time.
- * Key events in primate evolution include various phases of LINE retrotransposition and the emergence of new mobile elements like Alu and SVA, which may have affected brain development.
Advances in the synthesis and screening of small-molecule libraries have accelerated the discovery of chemical probes for studying biological processes. Still, only a small fraction of the human proteome has chemical ligands. Here, we describe a platform that marries fragment-based ligand discovery with quantitative chemical proteomics to map thousands of reversible small molecule-protein interactions directly in human cells, many of which can be site-specifically determined.
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