Publications by authors named "I Nagashima"
Aim: Assessing symptoms and daily functioning in patients with major depressive disorder (MDD) can be challenging, as their limited self-monitoring abilities may result in behavior observed during structured interviews not accurately reflecting their daily lives. This study aimed to determine if specific occupational behaviors could distinguish individuals with MDD from healthy individuals.
Methods: Baseline data were collected from medical records and activity programs.
Article Synopsis
- * A study analyzed data from 247 SMI patients who underwent OT, looking at their social activity status before hospitalization and one year post-discharge, factoring in OT participation and other demographic variables.
- * Findings revealed that higher OT participation rates, being socially active before hospitalization, and not having a marital history significantly predicted increased social activities after discharge.
Introduction: Difficult-to-treat depression (DTD) represents a broad spectrum of patients with persistent depression where standard treatment modalities are insufficient, yet specific characteristics of this group remain insufficiently understood. This investigation aims to delineate the sociodemographic and clinical profiles of suspected DTD patients in real-world clinical settings.
Method: We conducted a retrospective analysis of data from patients comprehensively evaluated for suspected DTD at Kyorin University Hospital, Tokyo, Japan, between October 2014 and September 2018.
Article Synopsis
- The study focuses on the importance of measuring hepatitis B surface antigen (HBsAg) for the management of chronic hepatitis B virus infection (CHB) and examines preS1 protein expression in patients.
- Researchers used seven monoclonal antibodies to analyze preS1 from various hepatitis B genotypes, discovering that the epitopes crucial for recognition are largely located in the aa33-47 region.
- Findings indicate that preS1 expression remains stable across different HBsAg levels and genotypes, emphasizing its potential as a therapeutic target in treating CHB.
Mucins are sugar-rich glycoproteins. Glycoprotein sugar moieties are structurally diverse, making it difficult to obtain naturally pure glycoproteins. Chemical synthesis is a powerful tool for obtaining target or designed compounds.
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