Publications by authors named "I N de Keijzer"
Article Synopsis
- Intraoperation hypotension (IOH) during surgery can have negative effects, leading to the routine use of norepinephrine (NE) to manage blood pressure under general anesthesia, although its pharmacokinetics during such conditions are not well understood.
- The study aimed to analyze the pharmacokinetics of NE in healthy volunteers in both awake and general anesthesia states, using a step-up dosing method and measuring plasma concentrations.
- Results indicated that a two-compartment model effectively described NE dynamics, finding that general anesthesia reduced NE clearance by 10%, with weight, age, and session (awake vs. anesthesia) being significant factors affecting its clearance.
Unlabelled: Post-induction hypotension (MAP < 65 mmHg) occurs frequently and is usually caused by the cardiovascular adverse effects of the anaesthetic induction drugs used. We hypothesize that a clinically significant difference in the incidence and severity of hypotension will be found when different doses of propofol and remifentanil are used for induction of anaesthesia.
Methods: This is a secondary analysis of a randomised controlled trial wherein four groups (A-D) of patients received one out of four different combinations of propofol and remifentanil, titrated to a predicted equipotency in probability of tolerance to laryngoscopy (PTOL) according to the Bouillon interaction model.
The difference between venous and arterial carbon dioxide pressure (pCO gap), has been used as a diagnostic and prognostic tool. We aimed to assess whether perioperative pCO gaps can predict postoperative complications. This was a secondary analysis of a multicenter RCT comparing goal-directed therapy (GDT) to standard care in which 464 patients undergoing high-risk elective abdominal surgery were included.
View Article and Find Full Text PDF