Dose-Response of Micronuclei in Binucleated and Mononucleated Lymphocytes from Cytochalasin Culture (Irradiation in vivo and in vitro).

The dose-responses of micronuclei (MN) in binucleated (BN) and mononucleated (MONO) lymphocytes cultivated with cytochalasin B (CBMN-assay) were studied. Irradiation of lymphocytes was performed in vitro (donor A) at the single dose of 1 and 2 Gy of (60)Co y-rays, or in vivo, during whole-body exposure of a cancer patient (donor B) to (60)Co γ-rays each day at a single dose of 0.115 Gy up to a total dose of 1.

[Before and after Chernobyl Accident (Memoirs, Researches Hypotheses)].

In the first part of the article the results of studies performed in the 1970-1980s on the progeny of irradiated animals (drosophila, mouse, rat) are presented. It was found that except severe disorders in this progeny named non target genetic radiation effects were observed (genome instability, increased cancer risk, impaired fitness) which were similar to the late somatic radiation effects. The hypothesis on the likeness of pathogenic nature of somatic and genetic effects of ionizing radiation was proposed.

[Frequency of chromosomal aberrations in lymphocytes of peripheral blood in patients with solid tumors].

There was carried out a study to compare the frequency of spontaneous chromosomal aberrations (CA) in lymphocytes of peripheral blood between the group of cancer patients with different types of solid tumors and the group of healthy people of the same age. There was established a significant increase in the average frequency of CA in cancer patients. Analysis of the group of patients has revealed its heterogeneity: in the majority of patients the individual frequency of CA significantly exceeded the average frequency of CA in the control group, in some - did not differ from that.

[Comparative evaluation of the predictive value of UroVysion and AURKA FISH tests of urine sediment cells for the diagnosis of bladder cancer].

Informative value of two tests based on FISH of exfoliated urothelial cells in urine sediment (AURKA and UroVysion) was compared in the group of patients (31 persons) with the history of bladder cancer. Coincidence in results of both FISH assays was found in 93.5%.

[Clinical and immunological efficiency of sodium nucleospermate in treating chronic endometritis and infertility complicated by HPV infection].

Clinical efficacy of sodium nucleospermate (SNS) has shown in the treatment of 26 female patients with chronic endometritis, unsuccessful attempts at in vitro fertilization, and persistent viral infection. Cells from endometrium were processed by liquid cytology and studied by immunocytochemistry techniques. It has been clearly established that, after SNS treatment, the frequency of CD20- and CD56-positive cells was significantly decreased (p < 0.