Activation of P-450-Dependent Monooxygenases Modulates the Diuretic Effect of Histochrome in Rats.

We studied the role of the liver monooxygenase system in pharmacological activity of histochrome, a pharmaceutical form of echinochrome A. In experiments on rats, benzonal, an inductor of the monooxygenase system of phenobarbytal type, significantly potentiated the diuretic effect of histochrome. Benzonal withdrawal was followed by a natriuretic reaction.

[Mitochondrial cytochrome b gene variation in brown bear (Ursus arctos Linnaeus, 1758) from southern part of Russian Far East].

The genetic variability of brown bear Ursus arctos from the southern part of the Russian Far East was first ex- amined based on the variations in the mitochondrial DNA cytochrome b sequence. The presence of two phylogenetic groups of haplotypes described previously for other parts of the species range was demonstrated. Part of the samples belonged to the haplotype group distributed across the whole range, while another part belonged to the rare group previously only reported for Japan and Alaska.

[Chromosomal variability of the Maximowicz's vole Microtus maximowiczii (Rodentia, Cricetidae, Microtus)].

The numeration of the chromosomes, which can be used to describe the karyotypes of various chromosomal forms from different geographical regions, has been proposed for the Maximowicz's vole Microtus maximowiczii. Application of FISH analysis has allowed us to show homology of Robertsonian rearregement (11/20) inkaryotypes of voles from Transbaikalia (2n = 41 and voles from Norsky reservation in Amur Region (2n = 40).

Worldwide genetic relationships of pigs as inferred from X chromosome SNPs.

The phylogeography of the porcine X chromosome has not been studied despite the unique characteristics of this chromosome. Here, we genotyped 59 single nucleotide polymorphisms (SNPs) in 312 pigs from around the world, representing 39 domestic breeds and wild boars in 30 countries. Overall, widespread commercial breeds showed the highest heterozygosity values, followed by African and American populations.

[Polymorphism of a short fragment of the mitochondrial genome control region (D-loop) in the Siberian roe deer Capreolus pygargus Pallas, 1771 (Artiodactyla, Cervidae) from the Russian Far East].

Genetic diversity of Siberian roe deer Capreolus pygargus, 1771 from the Russian Far East was studied based on polymorphism analysis of a mtDNA control region fragment (390 bp). Three phylogenetic lines were found in the animals examined. The trend for change of haplotypes of different phylogroups was shown to occur from north to south in Sikhote-Alin.