Publications by authors named "I N Savchenko"
Article Synopsis
- Low intra-tumor heterogeneity (ITH) is linked to better patient survival and response to immunotherapy, but the role of immune factors in tumor aggressiveness remains unclear.
- Researchers studied immune escape mechanisms in mouse tumors with low ITH, finding non-rejected clones had more tumor-associated macrophages and T-cell exhaustion compared to rejected ones.
- They identified Mif as a key factor in immune rejection; knocking it out led to smaller tumors and lower macrophage infiltration, a finding that was supported by data from melanoma patients.
Objective: Aim: To determine the state of relationship between anthropometric indicators and susceptibility to recurrent respiratory infections in preschool children.
Patients And Methods: Materials and Methods: A total of 143 children (73 boys and 70 girls) aged 12-59 months, undergoing inpatient treatment on acute respiratory infection, were involved in the clinical study. The number of acute respiratory infection episodes during a previous year of their lives was taken into account.
Article Synopsis
- FRET probes are useful for studying biochemical processes, specifically micelle formation from surfactants and chitosan derivatives.
- The study involved creating chitosan-based polymers with various functional groups, using characterization techniques like FTIR and NMR spectroscopy.
- The FRET effects were stronger in micelles than in aqueous solution, indicating that micelle formation forces the fluorophores closer together, useful for analyzing micelle properties like critical micelle concentration.
Objective: To study the results of surgical treatment in patients with perihilar tumors.
Material And Methods: We analyzed 98 patients with perihilar tumors who underwent surgery.
Results: We prefer percutaneous transhepatic biliary drainage (=58) for jaundice.
RNA interference (RNAi)-based therapeutics hold the potential for dominant genetic disorders, enabling sequence-specific inhibition of pathogenic gene products. We aimed to direct RNAi for the selective suppression of the heterozygous c.607 G > A variant causing encephalopathy.
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