Publications by authors named "I N Roberts"
Background: Adoptive transfer of autologous regulatory T cells (Tregs) is a promising therapeutic strategy aimed at enabling immunosuppression minimization following kidney transplantation. In our phase 1 clinical trial of Treg therapy in living donor renal transplantation, the ONE Study (ClinicalTrials.gov: NCT02129881), we observed focal lymphocytic infiltrates in protocol kidney transplant biopsies that are not regularly seen in biopsies of patients receiving standard immunosuppression.
View Article and Find Full Text PDFThe PrfA regulon of is induced by growth in low-oxygen microaerophilic conditions.
Microbiology (Reading)
November 2024
Article Synopsis
- The study focuses on how the food-borne pathogen adapts to low-oxygen (microaerophilic) conditions in the host's intestine, particularly looking at gene expression changes.
- The researchers used a variety of techniques, including transcriptional gene fusions and RNA sequencing, to analyze how different carbon sources (glucose vs. glycerol) affect the expression of the PrfA regulon, which is involved in virulence.
- Results indicated that the PrfA regulon is activated under low-oxygen conditions and is influenced by the type of carbon source available, highlighting the role of additional factors like SigB in this regulation.
Article Synopsis
- Approximately 65 million people experience mild traumatic brain injury (mTBI) each year, and fatigue is a significant symptom affecting many of them.
- The CRASH-3 trial studied the effects of tranexamic acid (TXA) on extreme fatigue in mTBI patients, finding that TXA did not significantly reduce fatigue compared to a placebo group.
- The results suggest that further research is necessary due to limitations such as non-prespecified analyses and the methods of measuring fatigue, indicating the need for follow-up studies to confirm these findings.
Article Synopsis
- The TMEM16A chloride channel is being studied as a potential treatment for cystic fibrosis by improving airway hydration and reducing symptoms.
- Research using Xenopus tadpole skin revealed that TMEM16A is present in cells similar to mammalian goblet cells and functions as a calcium-activated chloride channel.
- Deleting TMEM16A led to abnormal mucin maturation and disrupted mucus quality, indicating its critical role in maintaining a healthy mucus barrier.
Background: Tranexamic acid is a recommended treatment for women with a clinical diagnosis of postpartum haemorrhage, but whether it can prevent bleeding is unclear. We conducted a systematic review and individual patient data (IPD) meta-analysis of randomised controlled trials to assess the effects of tranexamic acid in women giving birth.
Methods: In this systematic review and IPD meta-analysis, we searched the WHO International Clinical Trials Registry Platform from database inception to Aug 4, 2024 for randomised trials that assessed the effects of tranexamic acid in women giving birth.