Microsporidians (M) are supposed to be ancient eukaryotic parasites with a broad range of animal hosts, being especially abundant in Arthropoda. They are supposed to pass a long way of adaptation to parasitism, that usually means inhibiting or avoiding host immune reactions alongside with the reduction of pathogenicity. However M, unlike other eukaryotic obligate parasites, preserved a high pathogenicity, comparable with one of viruses, and thus they could be expected to possess a unique mode of interactions with their hosts.
View Article and Find Full Text PDFX irradiation (4.3 Gy) of rats was shown to cause different reactions of the cyclic nucleotide system in differently reactive animals which was determined by the neutrophilic response in the peripheral blood after three-hour immobilization. Changes in the cyclic nucleotide content and in the activity of adenylate cyclase were found to occur in both hyper- and hyporeactive animals 24 h after irradiation.
View Article and Find Full Text PDFIt was shown that X-irradiation of rats (4.3 Gy), which were preliminarily divided into two groups by the neutrophilic reaction in the peripheral blood to the effect of a three-hour immobilization, induced different reactions of the cyclic nucleotide system. Thus, in animals hyper-reactive to stress radiation injury to the above system was severe: relative reactivity made 22.
View Article and Find Full Text PDFThree groups of breast cancer patients were investigated: with a high level of CEA, with a lowered level of CEA, and those in whom CEA was undetectable either before or after therapy. The relationship of the time course of blood CEA, nonspecific body reactivity, and radiotherapeutic efficacy was established. Ineffective radiotherapy resulted in inhibition of phagocytic activity of blood neutrophils and cell stromal reactions at a tumor bed against a decrease in CEA concentration as compared to the basal levels in patients.
View Article and Find Full Text PDF