Publications by authors named "I N Lavrov"
Article Synopsis
- A 37-year-old woman with spinal cord infarction experienced improved motor, sensory, and autonomic functions after undergoing transcutaneous spinal cord electrical stimulation (tSCS) for 20 months.
- Over the duration of the treatment, her motor and sensory scores increased significantly, and autonomic function related to bladder control showed notable improvement.
- The study also demonstrated partial recovery of muscle activity during voluntary movements, highlighting the potential of tSCS in spinal cord injury cases, suggesting the need for further research.
Article Synopsis
- Spinal cord stimulation (SCS) is an FDA-approved treatment for chronic pain, and researchers are using swine to enhance understanding and effectiveness of this treatment by studying the porcine spinal cord's morphology.
- The study involved high-resolution imaging of the spinal cord from Yorkshire/Landrace crossbred swine to create detailed 3D visualizations and compare their anatomy to previous research on human spinal cords.
- Results showed significant anatomical differences between porcine and human spinal cords, such as variations in rootlet counts and angles, suggesting caution when applying findings from swine models to human SCS treatment.
Article Synopsis
- Evoked compound action potentials (ECAPs) during spinal cord stimulation (SCS) are useful for understanding pain treatment and improving SCS control, but they are affected by various artifacts like capacitive noise, EMG bleed-through, and motion artifacts.
- A study using a swine model identified these artifacts and demonstrated that they can distort ECAP recordings, making it challenging to differentiate legitimate neural signals from interference.
- The research emphasizes the need for specific controls and procedures to accurately interpret ECAP data, which is crucial for advancing closed-loop SCS technologies.
Spinal cord epidural electrical stimulation (EES) has been successfully employed to treat chronic pain and to restore lost functions after spinal cord injury. Yet, the efficacy of this approach is largely challenged by the suboptimal spatial distribution of the electrode contacts across anatomical targets, limiting the spatial selectivity of stimulation. In this study, we exploited different ESS paradigms, designed as either Spatial-Selective Stimulation (SSES) or Orientation-Selective Epidural Stimulation (OSES), and compared them to Conventional Monopolar Epidural Stimulation (CMES).
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