[Clinical guidelines «Precocious puberty»].

The precocious puberty is an urgent problem of pediatric endocrinology characterized by clinical and pathogenetic heterogeneity. The appearance of secondary sex characteristics before the age of 8 years in girls and 9 years in boys requires timely diagnosis and the appointment of pathogenetically justified treatment in order to achieve the target indicators of final growth and prevent social deprivation. The developed clinical guidelines are the main working tool of the practitioner.

[Clinical guidelines «Obesity in children»].

Childhood obesity is an urgent problem of pediatric endocrinology due to the widespread occurrence, the development of metabolic complications and their steady tracking into adulthood. The developed clinical guidelines are the main working tool of the practitioner. They briefly and structurally present the main information about the epidemiology and modern classification of obesity, methods of its diagnosis and treatment based on the principles of evidence-based medicine.

[Clinical Findings in Two patients with DSD 46XY caused by new variant of the Gene and review of the literature of the role of DHH signaling pathway in sex development].

Mutations in the gene DHH are an extremely rare cause of disorders of sex development 46,XY (DSD,46XY). The article describes the clinical cases of two unrelated patients with gonadal dysgenesis 46,XY with female phenotype. By using a next generation sequencing method, in both cases the same biallelic variant substitution c.

[Influence of the iron saturation of bacteria on the phagocytic capacity of neutrophils].

The comparative study of the adsorptive capacity of human blood neutrophils with respect to "iron saturated" cells of bacteria belonging to different systematic groups was carried out. A decrease in the phagocytic number by 22-76% of the control level was shown. In experiments with iron-saturated Gram positive bacteria the phagocytic number was noted to be less than the physiological norm.

[Antibiotic resistance of hemolytic bacteria, depending on iron content in bacterial cells].

The study of sensitivity to antibiotic substances of different chemical structure and the mechanism of the antimicrobial action of hemolytic bacteria Bacillus sp., Corynebacterium sp. and Escherichia coli under the condition of high iron content in bacterial cells was carried out.