Publications by authors named "I N Karatsoreos"
Article Synopsis
- Traumatic brain injury (TBI) contributes to the risk of neurodegenerative diseases, but the link between acute TBI and ongoing brain degeneration remains poorly understood.
- A novel technique called needle-induced cavitation (NIC) was used on mouse brain slices to model TBI, focusing on the hippocampus, which is crucial for learning and memory and is susceptible to cognitive impairments.
- Combining NIC with electrophysiology revealed that this technique affects synaptic release in specific neurons and promotes neural repair through an extracellular matrix protein, providing insights for future research on TBI's impact and potential treatments.
Article Synopsis
- Traumatic brain injury (TBI) is linked to neurodegenerative diseases, but current understanding relies mostly on post-mortem studies with limited connections to injury dynamics and their cellular impacts.
- Needle-induced cavitation (NIC) is used to create small bubbles in brain tissue, allowing researchers to study the effects of TBI on living mouse brain slices, specifically targeting the hippocampus, a region crucial for learning and memory.
- The study shows that NIC alters synaptic function in the hippocampus and increases neural repair proteins, with these effects influenced by cannabinoid receptors, offering insights for future treatments targeting brain injury recovery.
Circadian regulation of autonomic tone and reflex pathways pairs physiological processes with the daily light cycle. However, the underlying mechanisms mediating these changes on autonomic neurocircuitry are only beginning to be understood. The brainstem nucleus of the solitary tract (NTS) and adjacent nuclei, including the area postrema and dorsal motor nucleus of the vagus, are key candidates for rhythmic control of some aspects of the autonomic nervous system.
View Article and Find Full Text PDFAdolescence is a period of development in which shifts in responses to glucocorticoids is well-documented. Obesity and metabolic syndrome are substantial health issues whose rates continue to rise in both adult and adolescent populations. Though many interacting factors contribute to these dysfunctions, how these shifts in glucocorticoid responses may be related remain unknown.
View Article and Find Full Text PDFDisruption of circadian rhythms, such as shift work and jet lag, are associated with negative physiological and behavioral outcomes, including changes in affective state, learning and memory, and cognitive function. The prefrontal cortex (PFC) is heavily involved in all of these processes. Many PFC-associated behaviors are time-of-day dependent, and disruption of daily rhythms negatively impacts these behavioral outputs.
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