Publications by authors named "I N Hulea"

Article Synopsis
  • * Early detection of multiple KAs is important for diagnosing underlying causes and preventing related health issues, which can improve patient quality of life and provide family counseling.
  • * Current research is limited and often based on small studies, so this work aims to review existing knowledge on multiple KAs, especially linked to genetic syndromes, and to propose a diagnostic algorithm for better clinical guidance.
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(1) Background: In a society with an advancing aging rate, medical systems are coming under pressure due to an increasing flow of older patients with multiple somatic diseases, exacerbated by their psychological and sociological backgrounds. We aimed to investigate the relationship between frailty and loneliness in older adults and to provide a holistic perspective on these concepts. Our research question was "Is there a link between the loneliness and frailty in older people?" (2) Methods: To assess the link between loneliness and frailty, we conducted a search accessing Index Medicus and PubMed; the timeframe of our research was from 2013 until 2023.

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Article Synopsis
  • * There is a noted but poorly defined connection between GD and cutaneous keratinocyte carcinomas, specifically non-melanoma skin cancers (NMSCs), with very few studies highlighting this relationship between 1983 and 2024.
  • * GD has been misdiagnosed as various NMSCs, and understanding this connection could provide insights into its underlying mechanisms, possibly reclassifying GD as a unique syndrome.
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Cutaneous melanoma is the most aggressive form of skin cancer and its incidence is unfortunately increasing. In the last decades, a progressive increase of new cases of diagnosed thin melanoma has been noted. This may be due to earlier detection, better surveillance, improved diagnostic criteria or increased exposure to sunlight.

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Non-melanoma skin cancer (NMSC) is the most common type of neoplasm affecting Caucasian individuals, with squamous-cell carcinoma (cSCC) being the second most common type of NMSC after basal-cell carcinoma. The immunohistochemical study of cSCC is of particular importance, especially for the diagnosis of its rare forms, for which accurate and early diagnosis is crucial for survival. In the present review of the literature, the potentially significant value of immunohistochemical markers were highlighted to more accurately assess the biological behaviour, the prognosis of cSCC and to optimize case management.

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