Viscossuplementation for the treatment of osteoarthritis of the knee: A protocol for an umbrella review of systematic reviews with meta-analyses of randomized controlled trials.

Background: Knee osteoarthritis (KOA) is a common chronic disease with worldwide prevalence of 10% to 79%, with costs ranging from $560 to $635 billion for year in United States of America. The main guidelines recommend interventions with undesirable adverse events (AE) or highly dependent on the patient's persistence. Thus, intra-articular (IA) therapies appear to be attractive in patients with KOA, as well as a valid therapy by maximizing effects locally in the joint and limiting systemic AE.

Polymorphisms in inflammasome genes and risk of asthma in Brazilian children.

Considering its role in inflammation and recently described "alternative" roles in epithelial homeostasis and Th1/Th2 balance, we hypothesize that inflammasome genetics could contribute to the development of asthma. Selected functional polymorphisms in inflammasome genes are evaluated in a cohort of asthmatic children and their families. Gain-of-function NLRP1 variants rs11651270, rs12150220 and rs2670660 resulted significantly associated to asthma in trios (TDT) analysis; and rs11651270 and rs2670660 also with asthma severity and total IgE level in asthmatic children.

Neonatal screening for severe combined immunodeficiency in Brazil.

Objective: To apply, in Brazil, the T-cell receptor excision circles (TRECs) quantification technique using real-time polymerase chain reaction in newborn screening for severe combined immunodeficiency and assess the feasibility of implementing it on a large scale in Brazil.

Methods: 8715 newborn blood samples were collected on filter paper and, after DNA elution, TRECs were quantified by real-time polymerase chain reaction. The cutoff value to determine whether a sample was abnormal was determined by ROC curve analysis, using SSPS.

[Radiofrequency ablation of recurrent intrahepatic cholangiocarcinoma: a case report].

A 45-years-old patient with recurrent intrahepatic cholangiocarcinoma 3 years after resection is described. 2 sessions of percutaneous radiofrequency ablation (RFA) were performed and complete destruction of the tumor was achieved. The patient was followed-up for 15 months by means of power-Doppler, CT and tumor markers.

[Bolus percutaneous ethanol injections in hepatocellular carcinoma--clinical results].

Aim: To establish the effectiveness of large-volume percutaneous ethanol injection under general anesthesia (Shot-PEI) as a local method for destruction of large hepatocellular carcinoma (HCC).

Patients And Methods: 46 patients with 48 HCC were treated with Shot-PEI. 1-4 sessions per lesion were performed with 12-138 ml ethanol per session.