Publications by authors named "I N Danilova"
Immunodeficiency conditions, which are characterized by reduced immune activity that promotes the development of chronic diseases, are needed for efficient monitoring. A promising area of monitoring and early diagnosis of immunodeficiency diseases is the determination of metabolic biomarkers in the blood. In this work, we identified a set of lipid biomarkers of immunodeficiency states by performing high-performance liquid chromatography-high-resolution mass spectrometry (HPLC-HRMS) analysis of blood plasma samples from mice and processing them with bioinformatics approaches.
View Article and Find Full Text PDFMedulloblastoma, the most prevalent brain tumor among children, requires a comprehensive understanding of its cellular characteristics for effective research and treatment. In this study, we focused on DAOY, a permanent cell line of medulloblastoma, and investigated the unique properties of DAOY cells when cultured as floating multicellular aggregates called spheres, as opposed to adherent monolayers. Through our comprehensive analysis, we identified distinct characteristics associated with DAOY spheres.
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- The study details a case of acute humoral rejection (AMR) in a heart transplant patient who had a history of hypertrophic cardiomyopathy and chronic myocarditis.
- After the transplant, the patient faced complications like pneumonia, leading to reduced immunosuppressive therapy.
- Tragically, the patient suffered a fatal hemodynamic collapse linked to autopsy findings of AMR with significant presence of CD16+ cells and SARS-CoV-2 Spike protein, highlighting the need for further research on the virus's impact on AMR.
Under the influence of inflammation, pancreatic β cells can transdifferentiate into cells with a different phenotype. When inflammation decreases, the opposite process is possible. We studied the effect of intramuscular injection of 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt (APH) on the structural and functional characteristics of the pancreatic islets in rats with experimental type 2 diabetes mellitus.
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- - Boron may improve the effectiveness of proton beam therapy in cancer treatment by enhancing cell damage in the targeted Bragg peak region through a specific nuclear reaction, although some studies have questioned this claim.
- - Experiments with prostate cancer and glioblastoma cells using 190 MeV proton beams showed that boron (from sodium mercaptododecaborate) significantly increased cell killing, especially at low concentrations and in the Bragg peak area.
- - The beneficial effects of boron occur through rare proton-boron reactions generating alpha particles, which lead to enhanced cell death, and this response seems to be amplified through interactions between cells, highlighting its potential for clinical use in treating certain tumors.