Supplementation of laying hens' feed with Schizochytrium powder and its effect on physical and chemical properties of eggs.

Biofortification enhances dietary quality and nutritional value using traditional marine microalga species, particularly docosahexaenoic acid (DHA), which is an essential n-3 fatty acid for human health. Eggs are natural fortified candidates. This study aimed to investigate the effect of dietary Schizochytrium powder on egg productivity, egg nutritional content, and fatty acid levels in laying hens.

Orally Bioavailable Proteolysis-Targeting Chimeras: An Innovative Approach in the Golden Era of Discovering Small-Molecule Cancer Drugs.

Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality that show promise to open a target space not accessible to conventional small molecules via a degradation-based mechanism. PROTAC degraders, due to their bifunctional nature, which is categorized as 'beyond the Rule of Five', have gained attention as a distinctive therapeutic approach for oral administration in clinical settings. However, the development of PROTACs with adequate oral bioavailability remains a significant hurdle, largely due to their large size and less than ideal physical and chemical properties.

Nickel-Catalyzed Deaminative Ketone Synthesis: Coupling of Alkylpyridinium Salts with Thiopyridine Esters via C-N Bond Activation.

A direct synthesis of ketones by the nickel-catalyzed deaminative cross-coupling of alkylpyridinium salts with thiopyridine esters has been reported. The reaction works well for both primary and secondary amines. This approach affords a highly valuable vista for the facile synthesis of ketones from easily accessible feedstock chemicals.

DenseRes-Unet: Segmentation of overlapped/clustered nuclei from multi organ histopathology images.

Cancer is the second deadliest disease globally that can affect any human body organ. Early detection of cancer can increase the chances of survival in humans. Morphometric appearances of histopathology images make it difficult to segment nuclei effectively.