Publications by authors named "I N Bodoev"
G-quadruplexes (G4), non-canonical secondary DNA structures, are intensively investigated for a long time. In eukaryotic organisms they play an important role in the regulation of gene expression and DNA repair. G4 have also been found in the genomes of numerous bacteria and archaea, but their functional role has not yet been fully explored.
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- G-quadruplexes (G4s) are unique DNA structures that may be targeted by antimicrobial compounds known as G4-stabilizing ligands, but their precise antibacterial mechanisms remain unclear.
- A study utilized genome-wide RNA-sequencing to assess how bacterial genes respond to two G4 ligands, BRACO-19 and TMPyP4, revealing significant changes in gene expression profiles.
- BRACO-19 affected genes related to replication, repair, and iron metabolism, while TMPyP4 influenced transcription factors and the arginine biosynthesis system, suggesting that different G4 ligands can impact various biological pathways.
There is growing concern about the emergence and spread of multidrug-resistant To effectively control antibiotic-resistant bacterial pathogens, it is necessary to develop new antimicrobials and to understand the resistance mechanisms to existing antibiotics. In this study, we discovered the unexpected onset of drug resistance in caused by amino acid substitutions in the periplasmic chaperone SurA and the β-barrel assembly machinery component BamA. Here, we investigated the i19.
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- * Researchers isolated and characterized three bacteriophages that infect multidrug-resistant bacteria with a specific capsule type, K23, showcasing similarities in their receptor-binding proteins.
- * The study revealed that recombinant depolymerases derived from these phages can target and help protect against infections caused by multidrug-resistant strains, highlighting the potential of bacteriophages in antimicrobial therapy.
[MOLECULAR MECHANISMS OF DRUG RESISTANCE NEISSERIA GONORRHOEAE HISTORY AND PROSPECTS].
Mol Gen Mikrobiol Virusol
December 2015
Neisseria gonorrhoeae (gonococcus) is a strict human pathogen, which causes gonorrhea--an infectious disease, whose origin dates back to more than two thousand years. Due to the unique plasticity of the genetic material, these bacteria have acquired the capacity to adapt to the host immune system, cause repeated infections, as well as withstand antimicrobials. Since the introduction of antibiotics in 1930s, gonococcus has displayed its propensity to develop resistance to all clinically useful antibiotics.
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