Publications by authors named "I N Albert"

Background: Utilization of diabetic care services remains a challenge among adult patients in low- and middle-income countries. Optimal utilization of diabetic care services could reduce morbidity and mortality and delay the development of long-term complications. This study assessed the utilization of basic diabetic care services and associated factors among diabetes mellitus patients at Mbarara Regional Referral Hospital in Western Uganda.

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The 24-item Social Provision Scale is among the most frequently used self-report scales to assess perceived social support. A shortened 10-item version (SPS-10) with promising psychometric properties has been proposed. However, so far only a few studies in specific cultural contexts investigated its psychometric properties.

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Twister ribozymes are an extensively studied class of nucleolytic RNAs. Thousands of natural twisters have been proposed using sequence homology and structural descriptors. Yet, most of these candidates have not been validated experimentally.

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Article Synopsis
  • CCR4-NOT is a complex involved in various stages of gene regulation like transcription, mRNA decay, and protein ubiquitylation, with extensive research in yeast but limited knowledge in mammals.
  • A study using an auxin-induced degron system showed that depleting key components CNOT1 and CNOT4 in human cells led to significant changes in mRNA stability and synthesis; CNOT1 depletion increased mRNA levels while CNOT4 depletion accelerated mRNA decay.
  • The results indicated that CCR4-NOT maintains the expression of certain transcriptional repressors (KZNFs), which in turn suppress retrotransposable elements (rTEs), establishing the complex as a crucial regulator of gene expression in mammals.
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Individuals diagnosed with autism, attachment disorders, emotionally unstable personality disorder (EUPD) or complex post-traumatic stress disorder (CPTSD) can present with similar features. This renders differential and accurate diagnosis of these conditions difficult, leading to diagnostic overshadowing and misdiagnosis. The purpose of this study was to explore professionals' perspectives on the differential diagnosis of autism, attachment disorders and CPTSD in young people; and of autism, CPTSD and EUPD in adults.

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