Inhibition of malignant potential and expression of proteins associated with epithelial-mesenchymal transition in Lewis lung carcinoma cells transduced with murine ifn-β gene in recombinant baculovirus.

Aim: To analyze biological characteristics, malignant potential and expression of proteins associated with epithelial-mesenchymal transition in murine lung carcinoma cells transduced with interferon-beta (ifn-β) gene in baculovirus vector.

Materials And Methods: The study was performed on Lewis lung carcinoma (LL) cells transduced with ifn-β gene in recombinant baculovirus vector. Biological characteristics of the LL cells were studied with the use of standard cell culture methods, cytogenetic and immunocytochemical assays.

Suppression of proliferation, tumorigenicity and metastasis of lung cancer cells after their transduction by interferon-beta gene in baculovirus vector.

Background: Gene therapy represents an interesting alternative treatment for cancers. Interferon-beta is well known as a multifunctional cytokine that provides antiviral, antiproliferative, antiangiogenic and immunomodulating effects. For this reason introduction of this cytokine gene in baculovirus vector is seen as a rather promising tool for anticancer therapy.

Anisotropic system of quasiparticles in superfluid helium.

The thermodynamic properties of anisotropic quasiparticle systems of He II are considered for all degrees of anisotropy. It is shown that the thermodynamic functions of a strongly anisotropic phonon-roton system are mainly determined by rotons at all temperatures. Analytical expressions for the roton thermodynamic functions are obtained for all degrees of anisotropy.