Publications by authors named "I N Abdurasulova"
Article Synopsis
- The study analyzed homocysteine (HCy) and vitamin levels, as well as genotypes of key gene polymorphisms related to folate metabolism in children with early-stage multiple sclerosis (MS) and compared them with healthy controls and patients with long-term MS.
- Results showed elevated HCy levels in children at MS onset without any vitamin B6, B9, or B12 deficiencies, suggesting a unique metabolic issue rather than a general vitamin deficiency.
- The findings indicate that high HCy levels can serve as a marker for functional disorders in folate metabolism associated with pediatric MS, potentially guiding new prevention and treatment strategies.
Background: Data on genetic markers that determine the prognosis of multiple sclerosis (MS) is still limited. The association between galanin gene polymorphism rs948854 and prognosis of MS had been demonstrated earlier.
Objectives: To confirm earlier findings in a distinct from the previously studied cohort of patients, and to further characterized the rs948854 polymorphism as one of the candidates for the risk stratification in patients with MS.
The rate of symptom accumulation distinguishes between slowly and rapidly progressing forms of multiple sclerosis (MS). Given that a patient's genetics can affect the rate of disease progression, identification of genetic variants associated with rapid disease progression should provide valuable information for timely prognosis and development of optimal treatment plans. We hypothesized that the polymorphism rs2821557 in the human KCNA3 gene encoding a voltage-gated potassium channel Kv1.
View Article and Find Full Text PDF[The intestinal microbiota composition in patients with multiple sclerosis receiving different disease-modifying therapies DMT].
Zh Nevrol Psikhiatr Im S S Korsakova
May 2019
Aim: To describe characteristics of the intestinal microbiota in patients with multiple sclerosis (MS) treated with glatiramer acetate (GA) or fingolimode (FG) for understanding causal relationships between gut microbiota and autoimmune processes in MS patients.
Material And Methods: The study included 34 patients treated with GA (n=17) or FG (n=17). GA was used in a dose of 20 mg/kg subcutaneously once a day, FG in a dose of 0.
The biological effects of three probiotic strains K32, GT15, L3 and their mixture were studied using a model of dysbiosis induced in rats by antibiotics. It was found that after taking different probiotics intestinal microbiota changed in a strain-specific manner. The maximal activity against pathogens was revealed after the administration of a mixture of bacterial strains under study or a single strain of enterococci.
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