Publications by authors named "I Munyangaju"
Introduction: Cardiovascular diseases contribute significantly to global morbidity and mortality. MicroRNAs are crucial in the development and progression of these diseases by regulating gene expression in various cells and tissues. Their roles in conditions like atherosclerosis, heart failure, myocardial infarction, and arrhythmias have been widely researched.
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- Sleep disorders are common and linked to various health issues, increasing the risk of inflammatory, metabolic, and cardiovascular diseases through different mechanisms.
- The authors reviewed research up to June 2023, examining the connections between sleep disorders and cardiovascular diseases, including their diagnosis and treatment options.
- Key findings indicate that sleep disorders impact heart rate variability, hypertension, and obesity, ultimately affecting cardiovascular health, and highlight the need for more studies to understand these relationships and improve treatment approaches.
Introduction: Approximately 50 million people worldwide have epilepsy, with many not achieving seizure freedom. Organ-on-chip technology, which mimics organ-level physiology, could revolutionize drug development for epilepsy by replacing animal models in preclinical studies. The authors' goal is to determine if customized micro-physiological systems can lead to tailored drug treatments for epileptic patients.
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- Tuberculosis is a major global health issue, with children representing a significant proportion of cases and deaths, making early diagnosis challenging, especially in resource-limited settings.
- A multicenter study across Mozambique, South Africa, and Spain will assess the availability of imaging resources and radiation exposure for pediatric TB diagnosis, utilizing retrospective data and standardized surveys among clinicians and radiology staff.
- Data collected will include national inventories of imaging units, survey results on diagnostic practices, and analyses of radiation doses for children under 16, aiming to improve diagnosis and safety in pediatric TB management.
Malaria remains a major public health concern worldwide. Malaria is endemic in Mozambique, with seasonal fluctuations throughout the country. Although the number of malaria cases in Mozambique have dropped by 11% from 2020 to 2021, there are still hotspots in the country with persistent high incidence and low insecticide-treated bed net usage.
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