Publications by authors named "I Mourao Soares"
Objectives: To evaluate the color change and trans-amelodentinal cytotoxicity of a 22% carbamide peroxide (CP) bleaching gel containing different concentration of manganese oxide (MnO).
Material And Methods: Enamel/dentin discs adapted to artificial pulp chambers were distributed according to treatments: CN-No treatment; CP22%-22%CP; CP22 + 2MnO-22%CP + 2 mg/mLMnO; CP22% + 6MnO-22%CP + 6 mg/mLMnO; CP22% + 10MnO-22%CP + 10 mg/mLMnO applied for 2 h for 15 days. Color change-CC (ΔE and ΔWI) (n = 8) was determined at 5, 10, and 15-day periods (ANOVA/Sidak).
Objective: Germline and somatic drivers are identified in 30% and 40% of pheochromocytomas and paragangliomas (PPGLs), respectively. In this study, we investigated the genetic landscape of PPGLs in a Brazilian cohort.
Methods: We studied 182 index patients with PPGLs (116 females and 66 males), comprising 118 pheochromocytoma and 70 paraganglioma cases.
Malaria continues to afflict hundreds of millions of lives annually, causing substantial fatalities despite available vaccines endorsed by the World Health Organization (WHO). However, these vaccines lack efficacy against Plasmodium vivax (Pv). Concomitantly, a considerable part of residents from several Pv-endemic areas face malnutrition, compromising their immunity to diseases, including malaria.
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- Plasmodium vivax causes millions of malaria cases worldwide, highlighting the urgent need for effective vaccine development, especially given the lack of studies on specific vaccine candidates for this species.
- The merozoite protein CyRPA has shown promise as a vaccine candidate due to its essential role in the growth and invasion of P. falciparum, and preliminary studies suggest that PvCyRPA is better at providing protection compared to traditional malaria vaccine candidates.
- Research in Brazilian malaria-endemic areas indicates that PvCyRPA is immunogenic, eliciting a strong immune response with important B and T cell epitopes, supporting its potential inclusion in future malaria vaccine formulations targeting P. vivax