Publications by authors named "I Moravkova"
Background: Although neuromelanin-sensitive magnetic resonance imaging (NM-MRI) has been used to evaluate early neurodegeneration in Parkinson's disease, studies concentrating on the locus coeruleus (LC) in pre-dementia stages of dementia with Lewy bodies (DLB) are lacking.
Objectives: The aims were to evaluate NM-MRI signal changes in the LC in patients with mild cognitive impairment with Lewy bodies (MCI-LB) compared to healthy controls (HC) and to identify the cognitive correlates of the changes. We also aimed to test the hypothesis of a caudal-rostral α-synuclein pathology spread using NM-MRI of the different LC subparts.
Background: Functional connectivity changes in clinically overt neurodegenerative diseases such as dementia with Lewy bodies have been described, but studies on connectivity changes in the pre-dementia phase are scarce.
Objectives: We concentrated on evaluating striato-cortical functional connectivity differences between patients with Mild Cognitive Impairment with Lewy bodies and healthy controls and on assessing the relation to cognition.
Methods: Altogether, we enrolled 77 participants (47 patients, of which 35 met all the inclusion criteria for the final analysis, and 30 age- and gender-matched healthy controls, of which 28 met all the inclusion criteria for the final analysis) to study the seed-based connectivity of the dorsal, middle, and ventral striatum.
Background: Electrophysiological markers of prodromal dementia with Lewy bodies were described in the spectral domain. The sub-second temporal resolution may provide additional information.
Objective: To evaluate electroencephalography (EEG) microstates in patients with mild cognitive impairment with Lewy bodies and to assess the association between their temporal dynamics and the spectral marker.
Aim: The mumps outbreak in the Plzeň Region in 2011 was analysed retrospectively using the epidemiological, clinical, and laboratory data. Vaccine efficacy analysis was also conducted in various population groups.
Material And Methods: The routine procedure and standard form were used by the epidemiologists to collect data on the age, sex, place of residence, presence in collectivities, date of disease onset, type of complications and date of their onset, hospital admission, vaccination, and results of laboratory analyses.
Screening family and sexual contacts of HBsAg+ persons in the Pilsen region.
Epidemiol Mikrobiol Imunol
September 2012
The Aim Of The Study: To detect HBsAg-positive persons and to offer their family and sexual contacts, after screening for viral hepatitis B (VHB) markers, free vaccination against the infection.
Material And Methods: In collaboration with laboratories, all persons with confirmed HBsAg in the Pilsen Region (549,618 population) were prospectively detected. From these persons, the following data were collected: reason for examination, clinical diagnosis, and ethnicity/nationality.