Representation of Sex, Race and Ethnicity in MASH Randomised Controlled Trials: A Systematic Review and Meta-Analysis.

Background And Aims: Randomised controlled trials (RCTs) have historically underrepresented female, racial and ethnic minorities across various fields. This systematic review and meta-analysis aims to examine the global distribution, reporting and participation of diverse groups based on sex, race and ethnicity in trials focused on metabolic dysfunction-associated steatohepatitis (MASH).

Methods: PubMed and Cochrane Library databases were systematically searched for MASH RCTs (through December 13, 2024) that included any pharmacotherapy as an intervention arm.

Global Epidemiology and Implications of I148M Variant in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-analysis.

Background & Aims: rs738409 variant is a risk factor for onset and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to assess its global prevalence, clinical and histological characteristics, and long-term outcomes in patients with MASLD.

Methods: PubMed and Embase databases were searched until December 30, 2023, for observational studies on genotyped adults with MASLD.

Nematic versus Kekulé Phases in Twisted Bilayer Graphene under Hydrostatic Pressure.

We address the precise determination of the phase diagram of magic angle twisted bilayer graphene under hydrostatic pressure within a self-consistent Hartree-Fock method in real space, including all the remote bands of the system. We further present a novel algorithm that maps the full real-space density matrix to a 4×4 density matrix based on a SU(4) symmetry of sublattice and valley degrees of freedom. We find a quantum critical point between a nematic and a Kekulé phase, and show also that our microscopic approach displays a strong particle-hole asymmetry in the weak coupling regime.

Analysis of the Relationship Between Body Mass Index (BMI) and Dento-Skeletal Maturation: A Cross-Sectional Case-Control Study.

The aim of this cross-sectional study was to establish if there is a relationship between body mass index (BMI) and skeletodental development in young obese patients in comparison with normal-weight patients. The sample consisted of 178 individuals (115 normal weight, 37 overweight and 26 obese), aged 6 to 16 years, with a mean biological age of 11.96 ± 2.

Development and Evaluation of the Antibacterial Properties of an Experimental Herbal Gel Against Cariogenic Bacteria.

Background: Recently, products with antibacterial properties derived from medicinal plants have increased as an alternative to conventional drugs. Thus, this study aimed to formulate and evaluate the antibacterial activity of an experimental gel based on Grindelia tarapacana essential oil in a bacterial consortium.

Material And Methods: The composition of the essential oil (EO) was determined using gas chromatography-mass spectrometry (GC-MS).