Publications by authors named "I Modos"
Article Synopsis
- Despite progress in vaccinations, COVID-19 remains a significant risk for kidney transplant recipients (KTRs) due to their weakened immune response.
- A study of 120 KTRs revealed that their ability to produce neutralizing antibodies after receiving a booster shot of the mRNA vaccine BNT162b2 was noticeably lower and declined more rapidly than that of healthy individuals.
- Factors like age, reduced kidney function, and the use of mycophenolate mofetil were linked to this decreased antibody production, but overall, the type of antibodies produced was similar to those found in healthy subjects, without cross-reactivity to seasonal coronaviruses.
Background: Sodium-glucose cotransporter 2 inhibitors (SGLT-2i) are glucose-lowering agents used for the treatment of type 2 diabetes mellitus, which also improve heart failure and decrease the risk of cardiovascular complications. Epicardial adipose tissue (EAT) dysfunction was suggested to contribute to the development of heart failure. We aimed to elucidate a possible role of changes in EAT metabolic and inflammatory profile in the beneficial cardioprotective effects of SGLT-2i in subjects with severe heart failure.
View Article and Find Full Text PDFBackground: Booster doses of SARS-CoV-2 mRNA vaccines are commonly used in kidney transplant recipients (KTRs). However, there is uncertainty regarding the waning of vaccination responses and immunological safety in KTRs.
Methods: A total of 123 KTRs were included in the final analysis of this prospective observational cohort study.
Although severe acute respiratory syndrome coronavirus 2 messenger ribonucleic acid (SARS-CoV-2 mRNA) vaccines are effective in kidney transplant recipients (KTRs), their immune response to vaccination is blunted by immunosuppression. Other tools enhancing vaccination response are therefore needed. Interestingly, aligning vaccine administration with circadian rhythms (chronovaccination) has been shown to boost immune response.
View Article and Find Full Text PDFIntroduction: There is a strong impetus for the use of telemedicine for boosting early detection rates and enabling early treatment and remote monitoring of COVID-19 cases, particularly in chronically ill patients such as kidney transplant recipients (KTRs). However, data regarding the effectiveness of this practice are lacking.
Methods: In this retrospective, observational study with prospective data gathering we analyzed the outcomes of all confirmed COVID-19 cases ( = 955) in KTRs followed at our center between March 1, 2020, and April 30, 2022.